研究内容

視床と大脳皮質が構成するループ回路網は、注意、知覚、あるいは、意識の神経基盤であると考えられています。視床核に抑制投射する視床網様核は、視床核、あるいは、ループ回路の活動を制御し、注意、知覚を修飾します。このような視床網様核の神経細胞の解剖学的（分布、投射）、電気生理学的特性（感覚反応、バースト活動）を調べています。同種、異種感覚情報、あるいは、高次脳機能に関与する大脳皮質前頭前野の出力が、視床網様核の細胞に集約し、視床核細胞の感覚情報処理を制御することを示唆するこれまでの研究知見を踏まえ、視床網様核において、Bottom-upの感覚情報とTop-downの大脳皮質の出力がどのように干渉するか、また、視床網様核を介して、報酬系が注意、知覚を修飾する可能性を調べる実験を行っています。精神-神経疾患の背後にある注意、知覚の神経機構の問題の理解に貢献する研究知見を提供したいと思います。

Publications (Kimura, A.)

2024

Kimura A*.
Cross-modal sensitivities to auditory and visual stimulations in the first-order somatosensory thalamic nucleus. European Journal of Neuroscience in press (DOI: 101111/ejn.16510) (2024). *Corresponding author

2023

Kimura A*.
Alterations of sensory cell activity in the thalamic reticular nucleus by prefrontal cortex activation in anesthetized rats. European Journal of Neuroscience 58: 2469-2503 (2023). *Corresponding author

2021

Kimura A*.
Sound intensity-dependent multiple tonotopic organizations and complex sub-threshold alterations of auditory response across sound frequencies in the thalamic reticular nucleus. Neuroscience 475: 10-51 (2021). *Corresponding author

2020

Kimura A*.
Cross-modal modulation of cell activity by sound in first-order visual thalamic nucleus. Journal of Comparative Neurology 528: 1917-1941 (2020). *Corresponding author

Imbe H, Kimura A.
Significance of medial preoptic area among the subcortical and cortical areas that are related to pain regulation in the rats with stress-induced hyperalgesia Brain Research 1735: 146758 (2020).

2018

Kimura A*, Imbe H.
Robust subthreshold cross-model modulation of auditory response by cutaneous electrical stimulation in first- and higher-order auditory thalamic nuclei. Neuroscience 372: 161-180 (2018). *Corresponding author

Imbe H, Kimura A.
Increase of histone acetylation in the GABAergic neurons in the rostral ventromedial medulla associated with mechanical hypersensitivity after repeated restraint stress. Brain Research Bulletin 142:394-402 (2018).

2017

Kimura A*.
Robust interactions between the effects of auditory and cutaneous electrical stimulations on cell activities in the thalamic reticular nucleus. Brain Research 1661: 49-66 (2017). *Corresponding author

Imbe H, Kimura A.
Attenuation of pCREB and Egr1 expression in the insular and anterior cingulate cortices associated with enhancement of CFA-evoked mechanical hypersensitivity after repeated forced swim stress. Brain Research Bulletin 134: 253-261 (2017).

2016

Imbe H, Kimura A.
Repeated forced swim stress affects the expression of pCREB and ΔFosB and the acetylation of histone H3 in the rostral ventromedial medulla and locus coeruleus. Brain Research Bulletin, 127: 11-22 (2016).

2015

Kimura A*, Imbe H.
Anatomically structured burst spiking of thalamic reticular nucleus cells: implications for distinct modulations of sensory processing in lemniscal and non-lemniscal thalamocortical loop circuitries. European Journal of Neuroscience 41: 1276-93 (2015). *Corresponding author

Imbe H, Kimura A.
Repeated forced swim stress prior to complete Freund's adjuvant injection enhances mechanical hyperalgesia and attenuates the expression of pCREB and ΔFosB and the acetylation of histone H3 in the insular cortex of rat. Neuroscience 301: 12-25 (2015).

2014

Kimura A*.
Diverse subthreshold cross-modal sensory interactions in the thalamic reticular nucleus: implications for new pathways of cross-modal attentional gating function. European Journal of Neuroscience 39: 1405-1418 (2014). *Corresponding author

Imbe H, Kimura A, Donishi T, Kaneoke Y.
Repeated forced swim stress enhances CFA-evoked thermal hyperal gesia and affects the expressions of pCREB and c-FOS in the insular cortex. Neuroscienc 259: 1-11 (2014).

2013

Imbe H, Kimura A, Donishi T, Kaneoke Y.
Effects of restraint stress on glial activity in the rostral ventromedial medulla. Neuroscience 241:10-21 (2013).

2012

Kimura A*, Yokoi I, Imbe H, Donishi T, Kaneoke Y.
Auditory thalamic reticular nucleus of the rat: anatomical nodes for modulation of auditory and cross-modal sensory processing in the loop connectivity between the cortex and thalamus. Journal of Comparative Neurology 520:1457-1480 (2012). *Corresponding author

Kimura A*, Yokoi I, Imbe H, Donishi T, Kaneoke Y.
Distinctions in burst spiking between thalamic reticular nucleus cells projecting to the dorsal lateral geniculate and lateral posterior nuclei in the anesthetized rat. Neuroscience 226 : 208-226 (2012). *Corresponding author

Imbe H, Kimura A, Donishi T, Kaneoke Y.
Chronic restraint stress decreases glial fibrillary acidic protein and glutamate transporter in the periaqueductal gray matter. Neuroscience 223 : 209-218 (2012).

2011

Donishi T, Kimura A*, Imbe H, Yokoi I, Kaneoke Y.
Sub-threshold cross-modal sensory interaction in the thalamus: lemniscal auditory response in the medial geniculate nucleus is modulated by somatosensory stimulation. Neuroscience 174:200-215 (2011). *Corresponding author

2010

Kimura A*, Imbe H, Donishi T.
Efferent connections of an auditory area in the caudal insular cortex of the rat: anatomical nodes for cortical streams of auditory processing and cross-modal sensory interactions. Neuroscience 166: 1140-1157 (2010). *Corresponding author

Imbe H, Okamoto K, Donishi T, Senba E, Kimura A.
Involvement of descending facilitation from the rostral ventromedial medulla in the enhancement of formalin-evoked nocifensive behavior following repeated forced swim stress. Brain Research 1329: 103-112 (2010).

2009

Kimura A*, Imbe H, Donishi T.
Axonal projections of auditory cells with short and long response latencies in the medial geniculate nucleus: distinct topographies in the connection with the thalamic reticular nucleus. European Journal of Neuroscience, 30: 783-799 (2009). *Corresponding author

Imbe H, Okamoto K, Donishi T, Kawai S, Enoki K, Senba E, Kimura A.
Activation of ERK in the locus coeruleus following acute noxious stimulation. Brain Research 1263: 50-57 (2009).

2008

Imbe H, Kimura A, Okamoto K, Donishi T, Aikawa F, Senba E, Tamai Y.
Activation of ERK in the rostral ventromedial medulla is involved in hyperalgesia during peripheral inflammation. Brain Research 1187: 103-110 (2008).

2007

Kimura A*, Imbe H, Donishi T, Tamai Y.
Axonal projections of single auditory neurons in the thalamic reticular nucleus: implications for tonotopy-related gating function and cross-modal modulation. European Journal of Neuroscience 26: 3524-3535 (2007). *Corresponding author

Kimura A*, Donishi T, Okamoto K, Imbe H, Tamai Y.
Efferent connections of the ventral auditory area in the rat cortex: implications for auditory processing related to emotion. European Journal of Neuroscience 25: 2819-2834 (2007). *Corresponding author

Imbe H, Okamoto K, Aikawa F, Kimura A, Donishi T, Tamai Y, Iwai-Liao Y, Senba E.
Effects of peripheral inflammation on activation of p38 mitogen-activated protein kinase in the rostral ventromedial medulla. Brain Research 1134: 131-139 (2007).

Okamoto K, Imbe H, Kimura A, Donishi T, Tamai Y, Senba E.
Activation of central 5HT2A receptors reduces the craniofacial nociception of rats. Neuroscience 147: 1090-1102 (2007).

2006

Donishi T, Kimura A*, Okamoto K, Tamai Y.
“Ventral” area in the rat auditory cortex: a major auditory field connected with the dorsal division of the medial geniculate body. Neuroscience 141: 553-1567 (2006). *Corresponding author

Okamoto K, Kimura A, Donishi T, Imbe H, Yuko Nishie, Haruhiko Matsushita, Tamai Y, Senba E.
Contribution of peripheral 5-HT2A or 5-HT3 receptors to Fos expression in the trigeminal spinal nucleus produced by acute injury to the masseter muscle during persistent temporomandibular joint inflammation in rats. Neuroscience 143: 597-606 (2006).

Okamoto K, Kimura A, Donishi T, Imbe H, Goda K, Kawanishi K, Tamai Y, Senba E.
Persistent monoarthritis of the temporomandibular joint region enhances nocifensive behavior and lumbar spinal Fos expression after noxious stimulation to the hindpaw in rats. Experimental Brain Research 170: 358-367 (2006).

2005

Kimura A*, Donishi T, Okamoto K, Tamai Y.
Topography of projections from the primary and non-primary auditory cortical areas to the medial geniculate body and thalamic reticular nucleus in the rat. Neuroscience 135: 1325-1342 (2005). *Corresponding author

Okamoto K, Kimura A, Donishi T, Imbe H, Senba E, Tamai Y.
Central serotonin 3 receptors play an important role in the modulation of nociceptiveneural activity of trigeminal subnucleus caudalis and nocifensive orofacial behavior in rats with persistent temporomandibular joint inflammation. Neuroscience 135: 569-581 (2005).

Okamoto K, Imbe H, Tashiro A, Kimura A, Donishi T, Tamai Y, Senba E.
The role of peripheral 5HT2A and 5HT1A receptors on the orofacial formalin test in rats with persistent temporomandibular joint inflammation. Neuroscience 130: 465-474 (2005).

2004

Kimura A*, Donishi T, Okamoto K, Tamai Y.
Efferent connections of “posterodorsal” auditory area in the rat cortex: implications for auditory spatial processing. Neuroscience 128: 399-419 (2004). *Corresponding author

Hazama M, Kimura A*, Donishi T, Sakoda T, Tamai Y.
Topography of corticothalamic projections from the auditory cortex of the rat. Neuroscience 124: 655-667 (2004). *Corresponding author

Sakoda T, Kimura A, Donishi T, Kitano H, Tamai Y.
Presence and connections of auditory neurons in the rostrodorsal and rostrolateral parts of the thalamic reticular nuclei. Acta Oto-laryngologica (Supplementum) 553: 36-42 (2004).

2003

Kimura A*, Donishi T, Sakoda T, Hazama M, Tamai Y.
Auditory thalamic nuclei projections to the temporal cortex in the rat. Neuroscience 117: 1003-1016 (2003). *Corresponding author

2000

Kimura A*, Pavlides C.
Long-term potentiation/depotentiation are accompanied by complex changes in spontaneous unit activity in the hippocampus. Journal of Neurophysiology 84: 1894-1906 (2000).

Donishi T, Tamai Y, Kimura A.
Organization of two-tone facilitation in neurons of the primary auditory cortex in rats. In: Integrated Human Brain Science: Theory, Method Application (Music), T. Nakada (Ed.), 425-433 (2000), Elsevier Science B.V.

1998

Kimura A, Grigor'yan R, Asanuma H.
Long-term increases in neuronal activity in the motor cortex evoked by simultaneous stimulation of the thalamus and somatosensory cortex in cats. Neuroscience and Behavioral Physiology 29: 475-481 (1999).

Kimura A, Grigorian R, Asanuma H.
Long-term potentiation of neuronal activity of the motor cortex induced by co-activation of the thalamus and the sensory-motor cortex. Rossiiskii Fiziologicheskii Zhurnal imeni I.M. Sechenova, 84: 460-468 (1998).

1997

Caria MA, Kaneko T, Kimura A, Asanuma H.
Functional organization of the projection from area 2 to area 4g in the cat. Journal of Neurophysiology 77: 3107-3114 (1997).

1996

Kimura A*, Hamada Y, Kawai Y, Tamai Y.
Sensory response properties of cortical neurons in the anterior ectosylvian sulcus of cats: intracellular recording and labeling. Neuroscience Research 26: 357-367 (1996). *Corresponding author

Kimura A*, Melis F, Asanuma H.
Long-lasting changes of neuronal activity in the motor cortex of cats. NeuroReport 7: 869-872 (1996). *Corresponding author

Tamai Y, Kimura A.
Multiple integration of input and output in the cortex. NeuroReport 7: 2401-2405 (1996).

1995

Pavlides C, Kimura A, Magarinos A-M, McEwen BS.
Hippocampal homosynaptic long-term depression/depotentiation induced by adrenal steroids. Neuroscience 68: 379-385 (1995).

1994

Kimura A*, Caria MA, Melis F, Asanuma H.
Long-term potentiation within the cat motor cortex. NeuroReport 5: 372-2376 (1994). *Corresponding author

Pavlides C, Kimura A, Magarinos A-M, McEwen BS.
Type I adrenal steroid receptors prolong hippocampal long-term potentiation. NeuroReport 5: 2673-2677 (1994).

Hamada Y, Tamai Y, Miyashita E, Kimura A.
Evaluation of the functional connectivity in the nervous system using time dependent scatter diagrams. Brain Research 660: 209-215 (1994).

1993

Kimura A*.
Sensory response properties of cortical neurons in the anterior ectosylvian sulcus: extracellular recording and intracellular labeling. Wakayama medical reports 34: 19-34 (1993). *Corresponding author

1992

Kimura A*, Tamai Y.
Sensory response of cortical neurons in the anterior ectosylvian suclus, including the area evoking eye movement. Brain Research 575: 181-186 (1992). *Corresponding author

1991

Kimura A*, Tamai Y.
Relative positions of "oculomotor" region and sensory receptive fields in the anterior ectosylvian sulcus of the cat. Wakayama medical reports 33: 1-5 (1991). *Corresponding author

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